InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: WDR48

Summary

InnateDB Protein

IDBP-26455.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WDR48

Protein Name

WD repeat domain 48

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000307491

InnateDB Gene

IDBG-26453 (WDR48)

Protein Structure

UniProt Annotation

Function

Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 by enhancing the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12 and USP46, respectively. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. In case of infection by Herpesvirus saimiri, may play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. Induces lysosomal vesicle formation via interaction with Herpesvirus saimiri tyrosine kinase-interacting protein (TIP). Subsequently, TIP recruits tyrosine-protein kinase LCK, resulting in down-regulation of T-cell antigen receptor TCR. May play a role in generation of enlarged endosomal vesicles via interaction with TIP. In case of infection by papillomavirus HPV11, promotes the maintenance of the viral genome via its interaction with HPV11 helicase E1. {ECO:0000269PubMed:12196293, ECO:0000269PubMed:18082604, ECO:0000269PubMed:19075014}.

Subcellular Localization

Nucleus. Cytoplasm. Lysosome. Note=Mainly cytoplasmic. In case of infection by papillomavirus HPV11, translocates to the nucleus via its interaction with papillomavirus HPV11.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:12196293}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 79 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	79 [view]
Protein-Protein	79 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000724	double-strand break repair via homologous recombination
GO:0006974	cellular response to DNA damage stimulus
GO:0007283	spermatogenesis
GO:0007338	single fertilization
GO:0008584	male gonad development
GO:0016032	viral process
GO:0016579	protein deubiquitination
GO:0035264	multicellular organism growth
GO:0043588	skin development
GO:0048568	embryonic organ development
GO:0048705	skeletal system morphogenesis
GO:0048872	homeostasis of number of cells
GO:0050679	positive regulation of epithelial cell proliferation
GO:0072520	seminiferous tubule development
GO:1902525	regulation of protein monoubiquitination