InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Phf12

Summary

InnateDB Protein

IDBP-264699.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Phf12

Protein Name

PHD finger protein 12

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000103997

InnateDB Gene

IDBG-202013 (Phf12)

Protein Structure

UniProt Annotation

Function

Acts as a transcriptional repressor. Involved in recruitment of functional SIN3A complexes to DNA. Represses transcription at least in part through the activity of an associated histone deacetylase (HDAC). May also repress transcription in a SIN3A-independent manner through recruitment of functional AES complexes to DNA (By similarity). {ECO:0000250UniProtKB:Q96QT6}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed mainly in heart, brain, lung, liver and testis. {ECO:0000269PubMed:11390640}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001106	RNA polymerase II transcription corepressor activity
GO:0001222	transcription corepressor binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0035091	phosphatidylinositol binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0045892	negative regulation of transcription, DNA-templated