InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bag1

Summary

InnateDB Protein

IDBP-265268.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bag1

Protein Name

BCL2-associated athanogene 1

Synonyms

BAG-1; Rap46;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000103724

InnateDB Gene

IDBG-136600 (Bag1)

Protein Structure

UniProt Annotation

Function

Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli. {ECO:0000269PubMed:9873016}.

Subcellular Localization

Isoform 1: Nucleus.Isoform 2: Cytoplasm.

Disease Associations

Tissue Specificity

Isoform 2 is expressed in the heart, lung, kidney and spinal cord. Isoform 1 and isoform 2 are expressed in hematopoietic cell lines. The levels of isoform 2 are relatively constant in all the cell lines examined while the levels of isoform 1 are more variable (at protein level). Isoform 1 is expressed in the lung and kidney. Isoform 2 is expressed in various tissues, with highest levels in testis and stomach. {ECO:0000269PubMed:9396724, ECO:0000269PubMed:9679980}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 39 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	39 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0051087	chaperone binding
GO:0051219	phosphoprotein binding

Biological Process

GO:0001933	negative regulation of protein phosphorylation
GO:0006915	apoptotic process
GO:0030182	neuron differentiation
GO:0043066	negative regulation of apoptotic process
GO:0043525	positive regulation of neuron apoptotic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0070585	protein localization to mitochondrion
GO:2000672	negative regulation of motor neuron apoptotic process