InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dusp3

Summary

InnateDB Protein

IDBP-267247.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dusp3

Protein Name

dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)

Synonyms

2210015O03Rik; 5031436O03Rik; T-DSP11; VHR;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000102790

InnateDB Gene

IDBG-212400 (Dusp3)

Protein Structure

UniProt Annotation

Function

Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2 (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:16845380}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004721	phosphoprotein phosphatase activity
GO:0004725	protein tyrosine phosphatase activity
GO:0008138	protein tyrosine/serine/threonine phosphatase activity
GO:0016791	phosphatase activity
GO:0033549	MAP kinase phosphatase activity

Biological Process

GO:0000188	inactivation of MAPK activity
GO:0001701	in utero embryonic development
GO:0006470	protein dephosphorylation
GO:0016311	dephosphorylation
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0045931	positive regulation of mitotic cell cycle
GO:0046329	negative regulation of JNK cascade
GO:0050860	negative regulation of T cell receptor signaling pathway
GO:0050868	negative regulation of T cell activation
GO:0070373	negative regulation of ERK1 and ERK2 cascade

Cellular Component

GO:0001772	immunological synapse
GO:0005634	nucleus
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

MGI:1919599

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000340 Dual specificity phosphatase, catalytic domain
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR020405 Atypical dual specificity phosphatase, subfamily A
IPR020417 Atypical dual specificity phosphatase
IPR020422 Dual specificity phosphatase, subgroup, catalytic domain
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00102
PF00782

PRINTS

PR00700
PR01909
PR01908

PIRSF

SMART

SM00194
SM00195

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt