InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pias3

Summary

InnateDB Protein

IDBP-267422.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pias3

Protein Name

protein inhibitor of activated STAT 3

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000102692

InnateDB Gene

IDBG-176105 (Pias3)

Protein Structure

UniProt Annotation

Function

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Repressor of STAT3 signaling via inhibiting STAT3 DNA- binding and suppressing cell growth. Repressor of MITF transcriptional activity. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. {ECO:0000269PubMed:11060035, ECO:0000269PubMed:11709556, ECO:0000269PubMed:14596924}.

Subcellular Localization

Cytoplasm. Nucleus. Note=Mainly cytoplasmic but shuttles between the nucleus and cytoplasm. Transported to the nucleus on interaction with phosphorylated STAT3 (By similatity). Colocalizes with MITF in the nucleus. Colocalizes with GFI1 in nuclear dots.

Disease Associations

Tissue Specificity

Expressed in kidney, heart, spleen, brain and cerebellum; weak expression, if any, in liver and lung. {ECO:0000269PubMed:10854042, ECO:0000269PubMed:14596924}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 47 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	17 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	47 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0008270	zinc ion binding
GO:0015459	potassium channel regulator activity
GO:0019789	SUMO ligase activity
GO:0019899	enzyme binding
GO:0047485	protein N-terminus binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0009725	response to hormone
GO:0010628	positive regulation of gene expression
GO:0016925	protein sumoylation
GO:0033235	positive regulation of protein sumoylation
GO:0045838	positive regulation of membrane potential