Mus musculus Protein: Dennd5a
Summary
InnateDB Protein IDBP-268189.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dennd5a
Protein Name DENN/MADD domain containing 5A
Synonyms 1500012B19Rik; AJ245569; AW496491; mKIAA1091; ORF37; Rab6ip1;
Species Mus musculus
Ensembl Protein ENSMUSP00000102333
InnateDB Gene IDBG-206333 (Dennd5a)
Protein Structure
UniProt Annotation
Function Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (By similarity). {ECO:0000250}.
Subcellular Localization Golgi apparatus membrane {ECO:0000269PubMed:19141279}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017112 Rab guanyl-nucleotide exchange factor activity
GO:0017137 Rab GTPase binding
Biological Process
GO:0032313 regulation of Rab GTPase activity
Cellular Component
GO:0000139 Golgi membrane
GO:0005794 Golgi apparatus
GO:0016020 membrane
Protein Structure and Domains
PDB ID MGI:1201681
InterPro IPR001024 PLAT/LH2 domain
IPR001194 DENN domain
IPR004012 RUN
IPR005112 dDENN domain
IPR005113 uDENN domain
IPR008976 Lipase/lipooxygenase, PLAT/LH2
PFAM PF01477
PF02141
PF02759
PF03455
PF03456
PRINTS
PIRSF
SMART SM00308
SM00799
SM00593
SM00801
SM00800
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6PAL8
PhosphoSite PhosphoSite-Q6PAL8
TrEMBL
UniProt Splice Variant
Entrez Gene 19347
UniGene Mm.21904
RefSeq XP_006507526
MGI ID 3CWZ
MGI Symbol Dennd5a
OMIM
CCDS
HPRD
IMGT
EMBL AJ245569 AK048609 BC022119 BC060230 L40894
GenPept AAA78787 AAH22119 AAH60230 BAC33389 CAB55599