Version 5.4
Mus musculus Protein: Ncdn
Summary
InnateDB Protein IDBP-269437.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ncdn
Protein Name neurochondrin
Synonyms AU042419; mKIAA0607; MMS10-AE; Ms10ae; norbin;
Species Mus musculus
Ensembl Protein ENSMUSP00000101722
InnateDB Gene IDBG-189201 (Ncdn)
Protein Structure
UniProt Annotation
Function Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling. Required for the spatial learning process. Acts as a negative regulator of Ca(2+)- calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth. {ECO:0000269PubMed:15790563, ECO:0000269PubMed:18572016, ECO:0000269PubMed:20007903}.
Subcellular Localization Cytoplasm, cytosol. Cell projection, dendrite. Note=Localizes to somatic regions of neurons. {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in the neuronal, chondral and bone tissues. Expressed in dendrites. Enriched in the brain in the surface layer I-IV. In brains, protein level increases in male but decreases in female with advancing age (at protein level). In adult brains, it is highly expressed in the forebrain and hindbrain. Highly expressed in the hippocampus, piriform cortex, septum, amygdaloid complex, medial geniculate nucleus, inferior colliculus, cerebellar nuclei and the nuclei of the Vth, VIIth, and XIIth cranial nerves. In bone tissues, it is expressed in osteoblasts and osteocytes. {ECO:0000269PubMed:11162505, ECO:0000269PubMed:11445285, ECO:0000269PubMed:15007648, ECO:0000269PubMed:20007903}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0031175 neuron projection development
GO:0045453 bone resorption
GO:0048168 regulation of neuronal synaptic plasticity
Cellular Component
GO:0005829 cytosol
GO:0030425 dendrite
GO:0043005 neuron projection
GO:0043025 neuronal cell body
Protein Structure and Domains
PDB ID MGI:1347351
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Z0E0
PhosphoSite PhosphoSite-Q9Z0E0
TrEMBL
UniProt Splice Variant
Entrez Gene 26562
UniGene Mm.475214
RefSeq XP_006503182
MGI ID
MGI Symbol Ncdn
OMIM
CCDS CCDS18659
HPRD
IMGT
EMBL AB017608 AB017609 AB019041 AK002938 AK122327 AK154889 AK170502 AL606908 BC017126
GenPept AAH17126 BAA75226 BAA75227 BAA75228 BAA75229 BAB22468 BAC65609 BAE32905 BAE41841 CAM19265

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca