Version 5.4
Mus musculus Protein: Kcnab2
Summary
InnateDB Protein IDBP-270430.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Kcnab2
Protein Name potassium voltage-gated channel, shaker-related subfamily, beta member 2
Synonyms F5; I2rf5; Kcnb3; kv-beta-2;
Species Mus musculus
Ensembl Protein ENSMUSP00000101273
InnateDB Gene IDBG-206719 (Kcnab2)
Protein Structure
UniProt Annotation
Function Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. {ECO:0000269PubMed:8576199}.
Subcellular Localization Cytoplasm {ECO:0000305}.
Disease Associations
Tissue Specificity Strongest expression in brain and eye. Highest levels in brain detected in brainstem and diencephalon. Strong expression also detected in lung and heart. Moderate expression in kidney, T-lymphocytes and skeletal muscle. {ECO:0000269PubMed:1573677, ECO:0000269PubMed:8824288}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005249 voltage-gated potassium channel activity
GO:0005515 protein binding
Biological Process
GO:0002244 hematopoietic progenitor cell differentiation
GO:0006813 potassium ion transport
GO:0034765 regulation of ion transmembrane transport
GO:0051291 protein heterooligomerization
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005737 cytoplasm
GO:0016021 integral component of membrane
GO:0044224 juxtaparanode region of axon
Protein Structure and Domains
PDB ID MGI:109239
InterPro IPR005399 Potassium channel, voltage-dependent, beta subunit, KCNAB-related
IPR005400 Potassium channel, voltage-dependent, beta subunit, KCNAB1
IPR005401 Potassium channel, voltage-dependent, beta subunit, KCNAB2
IPR005402 Potassium channel, voltage-dependent, beta subunit, KCNAB3
IPR005983 Potassium channel, voltage-dependent, beta subunit, KCNAB
IPR023210 NADP-dependent oxidoreductase domain
PFAM PF00248
PRINTS PR01577
PR01578
PR01579
PR01580
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P62482
PhosphoSite PhosphoSite-P62482
TrEMBL E0CYS2
UniProt Splice Variant
Entrez Gene 16498
UniGene Mm.490885
RefSeq NP_001239585
MGI ID
MGI Symbol Kcnab2
OMIM
CCDS CCDS19000
HPRD
IMGT
EMBL AL611985 BC039178 L48983 U31908 U65592
GenPept AAA75174 AAB00829 AAB37263 AAH39178

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca