InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CHD3

Summary

InnateDB Protein

IDBP-27055.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHD3

Protein Name

chromodomain helicase DNA binding protein 3

Synonyms

Mi-2a; Mi2-ALPHA; ZFH;

Species

Homo sapiens

Ensembl Protein

ENSP00000369716

InnateDB Gene

IDBG-27053 (CHD3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 190 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	190 [view]
Protein-Protein	189 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0004003	ATP-dependent DNA helicase activity
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008270	zinc ion binding
GO:0016787	hydrolase activity
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006333	chromatin assembly or disassembly
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007051	spindle organization
GO:0016568	chromatin modification
GO:0032508	DNA duplex unwinding
GO:0051297	centrosome organization

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0016581	NuRD complex
GO:0045111	intermediate filament cytoskeleton

Protein Structure and Domains

PDB ID

InterPro

IPR000330 SNF2-related
IPR000953 Chromo domain/shadow
IPR001650 Helicase, C-terminal
IPR001965 Zinc finger, PHD-type
IPR006935 Helicase/UvrB domain
IPR009071 High mobility group box domain
IPR009462 Domain of unknown function DUF1086
IPR009463 Domain of unknown function DUF1087
IPR011011 Zinc finger, FYVE/PHD-type
IPR012957 CHD, C-terminal 2
IPR012958 CHD, N-terminal
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR016197 Chromo domain-like
IPR019787 Zinc finger, PHD-finger
IPR021006 Histone deacetylase complex, subunit 2/3
IPR023780 Chromo domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM