Version 5.4
Homo sapiens Protein: CALCR
Summary
InnateDB Protein IDBP-27064.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CALCR
Protein Name calcitonin receptor
Synonyms CRT; CT-R; CTR; CTR1;
Species Homo sapiens
Ensembl Protein ENSP00000353385
InnateDB Gene IDBG-27060 (CALCR)
Protein Structure
UniProt Annotation
Function This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
Biological Process
Cellular Component
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR001688 GPCR, family 2, calcitonin receptor
IPR001879 GPCR, family 2, extracellular hormone receptor domain
IPR003287 GPCR, family 2, calcitonin receptor family
PFAM PF02793
PRINTS PR00361
PR01350
PIRSF
SMART SM00008
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-P30988
TrEMBL X2J7C8
UniProt Splice Variant
Entrez Gene 799
UniGene Hs.489127
RefSeq
HUGO HGNC:1440
OMIM 114131
CCDS
HPRD 00239
IMGT
EMBL FN994993 KJ145324
GenPept AHN52047 CBN80565

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca