InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Enpp1

Summary

InnateDB Protein

IDBP-270711.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Enpp1

Protein Name

ectonucleotide pyrophosphatase/phosphodiesterase 1

Synonyms

4833416E15Rik; AI428932; C76301; CD203c; E-NPP1; Ly-41; M6S1; NPP1; Npps; PC-1; Pca; Pca-1; Pdnp1; ttw; twy;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000101159

InnateDB Gene

IDBG-138688 (Enpp1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003824	catalytic activity
GO:0004551	nucleotide diphosphatase activity
GO:0005044	scavenger receptor activity
GO:0005158	insulin receptor binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016787	hydrolase activity
GO:0030247	polysaccharide binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding
GO:0047429	nucleoside-triphosphate diphosphatase activity

Biological Process

GO:0006091	generation of precursor metabolites and energy
GO:0006796	phosphate-containing compound metabolic process
GO:0006898	receptor-mediated endocytosis
GO:0006955	immune response
GO:0008152	metabolic process
GO:0009143	nucleoside triphosphate catabolic process
GO:0030279	negative regulation of ossification
GO:0030308	negative regulation of cell growth
GO:0030505	inorganic diphosphate transport
GO:0030643	cellular phosphate ion homeostasis
GO:0030730	sequestering of triglyceride
GO:0031953	negative regulation of protein autophosphorylation
GO:0032869	cellular response to insulin stimulus
GO:0045599	negative regulation of fat cell differentiation
GO:0045719	negative regulation of glycogen biosynthetic process
GO:0046325	negative regulation of glucose import
GO:0046627	negative regulation of insulin receptor signaling pathway
GO:0046849	bone remodeling
GO:0050427	3'-phosphoadenosine 5'-phosphosulfate metabolic process

Cellular Component

GO:0005615	extracellular space
GO:0005765	lysosomal membrane
GO:0005886	plasma membrane
GO:0009986	cell surface

Protein Structure and Domains

PDB ID

MGI:97370

InterPro

IPR001212 Somatomedin B domain
IPR001604 DNA/RNA non-specific endonuclease
IPR002591 Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase
IPR017850 Alkaline-phosphatase-like, core domain
IPR020436 Somatomedin B, chordata
IPR020821 Extracellular Endonuclease, subunit A

PFAM

PF01033
PF01223
PF01663

PRINTS

PR00022

PIRSF

SMART

SM00201
SM00892
SM00477

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt