Version 5.4
Homo sapiens Protein: ENTPD3
Summary
InnateDB Protein IDBP-27096.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ENTPD3
Protein Name ectonucleoside triphosphate diphosphohydrolase 3
Synonyms CD39L3; HB6; NTPDase-3;
Species Homo sapiens
Ensembl Protein ENSP00000301825
InnateDB Gene IDBG-27094 (ENTPD3)
Protein Structure
UniProt Annotation
Function Has a threefold preference for the hydrolysis of ATP over ADP.
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed in adult brain, pancreas, spleen and prostate. Moderate or low expression is seen in most tissues. Not expressed in liver and peripheral blood leukocytes.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0017110 nucleoside-diphosphatase activity
GO:0017111 nucleoside-triphosphatase activity
Biological Process
GO:0009134 nucleoside diphosphate catabolic process
GO:0009143 nucleoside triphosphate catabolic process
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000407 Nucleoside phosphatase GDA1/CD39
PFAM PF01150
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O75355
PhosphoSite PhosphoSite-O75355
TrEMBL
UniProt Splice Variant
Entrez Gene 956
UniGene Hs.441145
RefSeq NP_001278889
HUGO HGNC:3365
OMIM 603161
CCDS CCDS2691
HPRD 16014
IMGT
EMBL AC104186 AF034840 AF039917 AK313322 BC029869 CH471055
GenPept AAC09236 AAC39884 AAH29869 BAG36127 EAW64600 EAW64601

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca