InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BNC1

Summary

InnateDB Protein

IDBP-27173.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BNC1

Protein Name

basonuclin 1

Synonyms

BNC; BSN1; HsT19447;

Species

Homo sapiens

Ensembl Protein

ENSP00000307041

InnateDB Gene

IDBG-27171 (BNC1)

Protein Structure

UniProt Annotation

Function

Likely to be a transcription factor specific for squamous epithelium and for the constituent keratinocytes at a stage either prior to or at the very beginning of terminal differentiation. May play a role in the differentiation of spermatozoa and oocytes.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Relocates to the midpiece of the flagellum during late spermiogenesis in spermatids. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in epidermis, testis and foreskin, and to a lower extent in thymus, spleen, mammary glands, placenta, brain and heart. {ECO:0000269PubMed:9687312}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006356	regulation of transcription from RNA polymerase I promoter
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0008284	positive regulation of cell proliferation
GO:0008544	epidermis development
GO:0042060	wound healing
GO:0050679	positive regulation of epithelial cell proliferation
GO:0051276	chromosome organization