InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PDE4A

Summary

InnateDB Protein

IDBP-27313.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDE4A

Protein Name

phosphodiesterase 4A, cAMP-specific

Synonyms

DPDE2; PDE4; PDE46;

Species

Homo sapiens

Ensembl Protein

ENSP00000341007

InnateDB Gene

IDBG-27301 (PDE4A)

Protein Structure

UniProt Annotation

Function

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. {ECO:0000269PubMed:11566027, ECO:0000269PubMed:17727341}.

Subcellular Localization

Isoform 1: Cytoplasm, perinuclear region.Isoform 2: Cytoplasm, perinuclear region. Cell projection, ruffle membrane.Isoform 4: Membrane; Peripheral membrane protein. Note=Isoform 4 has propensity for association with membranes.Isoform 6: Cytoplasm, perinuclear region.Isoform 7: Cytoplasm. Membrane. Note=Predominantly cytoplasmic.

Disease Associations

Tissue Specificity

Isoform 1 is widely expressed. Isoform 2 is abundant in liver, stomach, testis, thyroid and adrenal glands. It is also found in placenta, kidney, pancreas, ovary, uterus, skin, monocytes, mast cells, macrophages, as well as in bronchial smooth muscle. Isoform 6 is expressed at high levels in the heart and small intestine. It is also found in the brain, kidney, spleen, colon, salivary gland, ovary and peripheral blood lymphocytes. Isoform 7 is expressed predominantly in skeletal muscle and brain and at lower levels in the testis. Isoform 7 is expressed in the brain. Found in specific neuronal subpopulations in cortex, spinal cord and cerebellum (at protein level). {ECO:0000269PubMed:11306681, ECO:0000269PubMed:15738310, ECO:0000269PubMed:18095939}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	8 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity
GO:0005515	protein binding
GO:0030552	cAMP binding
GO:0046872	metal ion binding

Biological Process

GO:0006198	cAMP catabolic process
GO:0007165	signal transduction

Cellular Component

GO:0005829	cytosol
GO:0016020	membrane
GO:0032587	ruffle membrane
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR002073 3\'5\'-cyclic nucleotide phosphodiesterase, catalytic domain
IPR003607 HD/PDEase domain
IPR023088 3\'5\'-cyclic nucleotide phosphodiesterase

PFAM

PF00233

PRINTS

PR00387

PIRSF

SMART

SM00471

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt