InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SETD1A

Summary

InnateDB Protein

IDBP-27373.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SETD1A

Protein Name

SET domain containing 1A

Synonyms

KMT2F; Set1; Set1A;

Species

Homo sapiens

Ensembl Protein

ENSP00000262519

InnateDB Gene

IDBG-27371 (SETD1A)

Protein Structure

UniProt Annotation

Function

Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys- 9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with SETD1B suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. {ECO:0000269PubMed:12670868}.

Subcellular Localization

Nucleus speckle {ECO:0000269PubMed:17355966}. Chromosome {ECO:0000269PubMed:17355966}. Note=Localizes to a largely non- overlapping set of euchromatic nuclear speckles with SETD1B, suggesting that SETD1A and SETD1B each bind to a unique set of target genes.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.

Experimentally validated
Total	42 [view]
Protein-Protein	38 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0042800	histone methyltransferase activity (H3-K4 specific)