Version 5.4
Homo sapiens Protein: CNTROB
Summary
InnateDB Protein IDBP-27420.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CNTROB
Protein Name centrobin, centrosomal BRCA2 interacting protein
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000369614
InnateDB Gene IDBG-27418 (CNTROB)
Protein Structure
UniProt Annotation
Function Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis. {ECO:0000269PubMed:16275750}.
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269PubMed:16275750}. Note=Centriole-associated, asymmetrically localizes to the daughter centriole.
Disease Associations
Tissue Specificity Widely expressed (at protein level). Highly expressed in testis. Also expressed in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes. {ECO:0000269PubMed:16275750}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019904 protein domain specific binding
Biological Process
GO:0000910 cytokinesis
GO:0007099 centriole replication
GO:0051299 centrosome separation
Cellular Component
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005814 centriole
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8N137
PhosphoSite PhosphoSite-Q8N137
TrEMBL I3L465
UniProt Splice Variant
Entrez Gene 116840
UniGene Hs.732863
RefSeq NP_001032221
HUGO HGNC:29616
OMIM 611425
CCDS CCDS32557
HPRD 13991
IMGT
EMBL AC104581 AF141344 AF331638 AK074847 AL137669 AL833907 AY160226 AY160227 BC014055 BC021134
GenPept AAG49447 AAH14055 AAH21134 AAL56068 AAO22135 AAO22136 BAC11241 CAD38763 CAH10698

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca