Homo sapiens Protein: GUCY2D | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Protein | IDBP-27561.5 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | GUCY2D | ||||||||||||||||||
Protein Name | guanylate cyclase 2D, membrane (retina-specific) | ||||||||||||||||||
Synonyms | CORD5; CORD6; CYGD; GUC1A4; GUC2D; LCA; LCA1; RCD2; retGC; RETGC-1; ROS-GC1; ROSGC; | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Protein | ENSP00000254854 | ||||||||||||||||||
InnateDB Gene | IDBG-27557 (GUCY2D) | ||||||||||||||||||
Protein Structure | |||||||||||||||||||
UniProt Annotation | |||||||||||||||||||
Function | Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction. | ||||||||||||||||||
Subcellular Localization | Membrane; Single-pass type I membrane protein. | ||||||||||||||||||
Disease Associations | Leber congenital amaurosis 1 (LCA1) [MIM:204000]: A severe dystrophy of the retina, typically becoming evident in the first years of life. Visual function is usually poor and often accompanied by nystagmus, sluggish or near-absent pupillary responses, photophobia, high hyperopia and keratoconus. {ECO:0000269PubMed:11035546, ECO:0000269PubMed:12365911, ECO:0000269PubMed:17724218, ECO:0000269PubMed:21602930, ECO:0000269PubMed:8944027}. Note=The disease is caused by mutations affecting the gene represented in this entry.Cone-rod dystrophy 6 (CORD6) [MIM:601777]: An inherited retinal dystrophy characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa. {ECO:0000269PubMed:12552567, ECO:0000269PubMed:9618177, ECO:0000269PubMed:9683616}. Note=The disease is caused by mutations affecting the gene represented in this entry. | ||||||||||||||||||
Tissue Specificity | Retina. Localized exclusively in the nuclei and inner segments of the rod and cone photoreceptor cells. | ||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||
PDB ID | |||||||||||||||||||
InterPro |
IPR000719
Protein kinase domain IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain IPR001828 Extracellular ligand-binding receptor IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain IPR011009 Protein kinase-like domain IPR011645 Haem NO binding associated IPR020635 Tyrosine-protein kinase, catalytic domain IPR028082 Periplasmic binding protein-like I IPR029787 Nucleotide cyclase |
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PFAM |
PF00069
PF00211 PF07714 PF01094 PF07701 |
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PRINTS |
PR00109
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PIRSF | |||||||||||||||||||
SMART |
SM00044
SM00220 SM00219 |
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TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | Q02846 | ||||||||||||||||||
PhosphoSite | PhosphoSite-Q02846 | ||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 3000 | ||||||||||||||||||
UniGene | Hs.592109 | ||||||||||||||||||
RefSeq | NP_000171 | ||||||||||||||||||
HUGO | HGNC:4689 | ||||||||||||||||||
OMIM | 600179 | ||||||||||||||||||
CCDS | CCDS11127 | ||||||||||||||||||
HPRD | 02550 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AJ222657 L26921 M92432 | ||||||||||||||||||
GenPept | AAA60366 AAA60547 CAA10914 | ||||||||||||||||||