InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC44A2

Summary

InnateDB Protein

IDBP-27876.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC44A2

Protein Name

solute carrier family 44, member 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000336888

InnateDB Gene

IDBG-27872 (SLC44A2)

Protein Structure

UniProt Annotation

Function

Isoform 1, but not isoform 3, exhibits some choline transporter activity. {ECO:0000269PubMed:10677542, ECO:0000269PubMed:20665236}.

Subcellular Localization

Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Present in supporting cells of the inner ear (at protein level). Only isoform 3 is expressed in inner ear vestibular tissue. {ECO:0000269PubMed:14973250, ECO:0000269PubMed:20665236}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0015220	choline transmembrane transporter activity

Biological Process

GO:0006644	phospholipid metabolic process
GO:0006656	phosphatidylcholine biosynthetic process
GO:0007165	signal transduction
GO:0015871	choline transport
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0044281	small molecule metabolic process
GO:0046474	glycerophospholipid biosynthetic process
GO:0055085	transmembrane transport