InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: YWHAQ

Summary

InnateDB Protein

IDBP-27935.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

YWHAQ

Protein Name

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide

Synonyms

14-3-3; 1C5; HS1;

Species

Homo sapiens

Ensembl Protein

ENSP00000371267

InnateDB Gene

IDBG-27933 (YWHAQ)

Protein Structure

UniProt Annotation

Function

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. {ECO:0000269PubMed:12177059}.

Subcellular Localization

Cytoplasm. Note=In neurons, axonally transported to the nerve terminals.

Disease Associations

Tissue Specificity

Abundantly expressed in brain, heart and pancreas, and at lower levels in kidney and placenta. Up-regulated in the lumbar spinal cord from patients with sporadic amyotrophic lateral sclerosis (ALS) compared with controls, with highest levels of expression in individuals with predominant lower motor neuron involvement. {ECO:0000269PubMed:11080204}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 518 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	518 [view]
Protein-Protein	516 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019904	protein domain specific binding
GO:0047485	protein N-terminus binding
GO:0071889	14-3-3 protein binding

Biological Process

GO:0006605	protein targeting
GO:0006915	apoptotic process
GO:0007264	small GTPase mediated signal transduction
GO:0021762	substantia nigra development
GO:0045892	negative regulation of transcription, DNA-templated
GO:0061024	membrane organization
GO:0097193	intrinsic apoptotic signaling pathway
GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane
GO:0030659	cytoplasmic vesicle membrane
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome