InnateDB Protein
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IDBP-27937.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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YWHAQ
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Protein Name
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tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
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Synonyms
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14-3-3; 1C5; HS1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000238081
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InnateDB Gene
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IDBG-27933 (YWHAQ)
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Protein Structure
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Function |
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. {ECO:0000269PubMed:12177059}.
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Subcellular Localization |
Cytoplasm. Note=In neurons, axonally transported to the nerve terminals.
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Disease Associations |
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Tissue Specificity |
Abundantly expressed in brain, heart and pancreas, and at lower levels in kidney and placenta. Up-regulated in the lumbar spinal cord from patients with sporadic amyotrophic lateral sclerosis (ALS) compared with controls, with highest levels of expression in individuals with predominant lower motor neuron involvement. {ECO:0000269PubMed:11080204}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 518 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated |
Total |
518
[view]
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Protein-Protein |
516
[view]
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Protein-DNA |
0
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Protein-RNA |
1
[view]
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
15 [view]
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Molecular Function |
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Biological Process |
GO:0006915
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apoptotic process
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GO:0021762
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substantia nigra development
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GO:0045892
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negative regulation of transcription, DNA-templated
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GO:0061024
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membrane organization
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GO:0097193
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intrinsic apoptotic signaling pathway
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GO:1900740
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positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
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Cellular Component |
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PDB ID |
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InterPro |
IPR000308
14-3-3 protein
IPR023410
14-3-3 domain
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PFAM |
PF00244
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PRINTS |
PR00305
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PIRSF |
PIRSF000868
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SMART |
SM00101
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TIGRFAMs |
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Modification |
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SwissProt |
P27348
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PhosphoSite |
PhosphoSite-P27348
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TrEMBL |
Q53S41
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UniProt Splice Variant |
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Entrez Gene |
10971
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UniGene |
Hs.74405
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RefSeq |
NP_006817
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HUGO |
HGNC:12854
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OMIM |
609009
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CCDS |
CCDS1666
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HPRD |
00886
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IMGT |
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EMBL |
AC073195
AC082651
AF070556
AK302208
AK316158
BC050601
BC056867
BC093019
BT020014
CH471053
X56468
X57347
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GenPept |
AAC28640
AAH50601
AAH56867
AAH93019
AAV38817
AAX93143
AAY24326
BAG63566
BAH14529
CAA39840
CAA40622
EAX00977
EAX00979
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