InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CDS1

Summary

InnateDB Protein

IDBP-27940.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDS1

Protein Name

CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1

Synonyms

CDS;

Species

Homo sapiens

Ensembl Protein

ENSP00000295887

InnateDB Gene

IDBG-27938 (CDS1)

Protein Structure

UniProt Annotation

Function

Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol (PtdIns), phosphatidylglycerol, and cardiolipin. Overexpression may amplify cellular signaling responses from cytokines. May also play an important role in the signal transduction mechanism of retina and neural cells.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Cytoplasmic aspect of the endoplasmic reticulum. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in adult tissues such as placenta, brain, small intestine, ovary, testis and prostate. Highly expressed in fetal kidney, lung and brain. Lower level in fetal liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004142	diacylglycerol cholinephosphotransferase activity
GO:0004605	phosphatidate cytidylyltransferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006644	phospholipid metabolic process
GO:0006657	CDP-choline pathway
GO:0006661	phosphatidylinositol biosynthetic process
GO:0007165	signal transduction
GO:0007602	phototransduction
GO:0016024	CDP-diacylglycerol biosynthetic process
GO:0044281	small molecule metabolic process
GO:0046474	glycerophospholipid biosynthetic process