Version 5.4
Homo sapiens Protein: HHATL
Summary
InnateDB Protein IDBP-28006.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HHATL
Protein Name hedgehog acyltransferase-like
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000310621
InnateDB Gene IDBG-28004 (HHATL)
Protein Structure
UniProt Annotation
Function Negatively regulates N-terminal palmitoylation of SHH by HHAT/SKN. {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Heart-specific. {ECO:0000269PubMed:11374908}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0060262 negative regulation of N-terminal protein palmitoylation
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR004299 Membrane bound O-acyl transferase, MBOAT
PFAM PF03062
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9HCP6
PhosphoSite PhosphoSite-
TrEMBL C9JL39
UniProt Splice Variant
Entrez Gene 57467
UniGene Hs.727842
RefSeq XP_006713336
HUGO HGNC:13242
OMIM 608116
CCDS CCDS2704
HPRD 12166
IMGT
EMBL AB032999 AB042554 AC006059 BC022529 CH471055
GenPept AAH22529 BAA86487 BAB17758 EAW64666 EAW64667 EAW64668

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca