Version 5.4
Homo sapiens Protein: TMEM55A
Summary
InnateDB Protein IDBP-28242.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TMEM55A
Protein Name transmembrane protein 55A
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000285419
InnateDB Gene IDBG-28240 (TMEM55A)
Protein Structure
UniProt Annotation
Function Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate. Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4- bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3- monophosphate. {ECO:0000269PubMed:16365287}.
Subcellular Localization Late endosome membrane {ECO:0000269PubMed:16365287}; Multi-pass membrane protein {ECO:0000269PubMed:16365287}. Lysosome membrane {ECO:0000269PubMed:16365287}; Multi-pass membrane protein {ECO:0000269PubMed:16365287}.
Disease Associations
Tissue Specificity Ubiquitous. {ECO:0000269PubMed:16365287}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0016787 hydrolase activity
Biological Process
GO:0008152 metabolic process
Cellular Component
GO:0005765 lysosomal membrane
GO:0016021 integral component of membrane
GO:0031902 late endosome membrane
Protein Structure and Domains
PDB ID
InterPro IPR019178 Transmembrane protein 55A/B
PFAM PF09788
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8N4L2
PhosphoSite PhosphoSite-Q8N4L2
TrEMBL
UniProt Splice Variant
Entrez Gene 55529
UniGene Hs.658908
RefSeq NP_061180
HUGO HGNC:25452
OMIM 609864
CCDS CCDS6252
HPRD 13233
IMGT
EMBL AK313783 BC033892 CH471060 CR749733
GenPept AAH33892 BAG36521 CAH18492 EAW91672

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca