Version 5.4
Homo sapiens Protein: SLC38A4
Summary
InnateDB Protein IDBP-28653.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC38A4
Protein Name solute carrier family 38, member 4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000266579
InnateDB Gene IDBG-28651 (SLC38A4)
Protein Structure
UniProt Annotation
Function Sodium-dependent amino acid transporter. Mediates electrogenic symport of neutral amino acids and sodium ions. Has a broad specificity, with a preference for Ala, followed by His, Cys, Asn, Ser, Gly, Val, Thr, Gln and Met. May mediate sodium- independent transport of cationic amino acids, such as Arg and Lys. Amino acid uptake is pH-dependent, with low transport activities at pH 6.5, intermediate at pH 7.0 and highest between pH 7.5 and 8.5. {ECO:0000269PubMed:11342143, ECO:0000269PubMed:11414754}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:11414754, ECO:0000269PubMed:16148032}; Multi-pass membrane protein {ECO:0000269PubMed:11414754, ECO:0000269PubMed:16148032}.
Disease Associations
Tissue Specificity Detected in embryonic and adult liver, and at lower levels in adult muscle, kidney and pancreas. Detected in placenta syncytiotrophoblasts throughout gestation. Detected in fetal blood vessels. {ECO:0000269PubMed:11342143, ECO:0000269PubMed:11414754, ECO:0000269PubMed:16148032}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0015293 symporter activity
Biological Process
GO:0006811 ion transport
GO:0006814 sodium ion transport
GO:0006865 amino acid transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR013057 Amino acid transporter, transmembrane
PFAM PF01490
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q969I6
PhosphoSite PhosphoSite-Q969I6
TrEMBL F8VRD9
UniProt Splice Variant
Entrez Gene 55089
UniGene Hs.694012
RefSeq NP_060488
HUGO HGNC:14679
OMIM 608065
CCDS CCDS8750
HPRD 12159
IMGT
EMBL AB055003 AC008014 AC080136 AF193836 AF305814 AK291168 BC069819 BC101827 BC104913 CH471111
GenPept AAH69819 AAI01828 AAI04914 AAK43528 AAK71508 BAB84090 BAF83857 EAW57919 EAW57920

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca