InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SMURF1

Summary

InnateDB Protein

IDBP-28875.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SMURF1

Protein Name

SMAD specific E3 ubiquitin protein ligase 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000355326

InnateDB Gene

IDBG-28871 (SMURF1)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. {ECO:0000269PubMed:10458166, ECO:0000269PubMed:19937093, ECO:0000269PubMed:21402695}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:21572392}. Cell membrane {ECO:0000269PubMed:21572392}; Peripheral membrane protein {ECO:0000269PubMed:21572392}; Cytoplasmic side {ECO:0000269PubMed:21572392}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 441 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	441 [view]
Protein-Protein	433 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	8 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0016874	ligase activity
GO:0048185	activin binding
GO:0070411	I-SMAD binding
GO:0070412	R-SMAD binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0006611	protein export from nucleus
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007398	ectoderm development
GO:0016567	protein ubiquitination
GO:0030154	cell differentiation
GO:0030509	BMP signaling pathway
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030514	negative regulation of BMP signaling pathway
GO:0030579	ubiquitin-dependent SMAD protein catabolic process
GO:0032801	receptor catabolic process
GO:0034394	protein localization to cell surface
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process