InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HMGCR

Summary

InnateDB Protein

IDBP-28897.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HMGCR

Protein Name

3-hydroxy-3-methylglutaryl-CoA reductase

Synonyms

LDLCQ3;

Species

Homo sapiens

Ensembl Protein

ENSP00000287936

InnateDB Gene

IDBG-28893 (HMGCR)

Protein Structure

UniProt Annotation

Function

Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.

Subcellular Localization

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.

Experimentally validated
Total	14 [view]
Protein-Protein	13 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004420	hydroxymethylglutaryl-CoA reductase (NADPH) activity
GO:0005515	protein binding
GO:0008158	hedgehog receptor activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0042282	hydroxymethylglutaryl-CoA reductase activity
GO:0042803	protein homodimerization activity
GO:0050661	NADP binding
GO:0050662	coenzyme binding
GO:0070402	NADPH binding

Biological Process

GO:0006695	cholesterol biosynthetic process
GO:0006743	ubiquinone metabolic process
GO:0007568	aging
GO:0007584	response to nutrient
GO:0008284	positive regulation of cell proliferation
GO:0008299	isoprenoid biosynthetic process
GO:0008542	visual learning
GO:0010664	negative regulation of striated muscle cell apoptotic process
GO:0010666	positive regulation of cardiac muscle cell apoptotic process
GO:0015936	coenzyme A metabolic process
GO:0032874	positive regulation of stress-activated MAPK cascade
GO:0043066	negative regulation of apoptotic process
GO:0043407	negative regulation of MAP kinase activity
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0045445	myoblast differentiation
GO:0045471	response to ethanol
GO:0045908	negative regulation of vasodilation
GO:0048643	positive regulation of skeletal muscle tissue development
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0051262	protein tetramerization
GO:0055114	oxidation-reduction process
GO:0061045	negative regulation of wound healing
GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0070374	positive regulation of ERK1 and ERK2 cascade

Cellular Component

GO:0005778	peroxisomal membrane
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

InterPro

IPR000731 Sterol-sensing domain
IPR002202 Hydroxymethylglutaryl-CoA reductase, class I/II
IPR003392 Patched
IPR004554 Hydroxymethylglutaryl-CoA reductase, eukaryotic/arcaheal type
IPR004816 Hydroxymethylglutaryl-CoA reductase, metazoan
IPR009023 Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain
IPR009029 Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain

PFAM

PF00368
PF02460

PRINTS

PR00071

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P04035