InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HMGCR

Summary

InnateDB Protein

IDBP-28899.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HMGCR

Protein Name

3-hydroxy-3-methylglutaryl-CoA reductase

Synonyms

LDLCQ3;

Species

Homo sapiens

Ensembl Protein

ENSP00000340816

InnateDB Gene

IDBG-28893 (HMGCR)

Protein Structure

UniProt Annotation

Function

Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.

Subcellular Localization

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.

Experimentally validated
Total	14 [view]
Protein-Protein	13 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004420	hydroxymethylglutaryl-CoA reductase (NADPH) activity
GO:0005515	protein binding
GO:0008158	hedgehog receptor activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0042282	hydroxymethylglutaryl-CoA reductase activity
GO:0050661	NADP binding
GO:0050662	coenzyme binding
GO:0070402	NADPH binding

Biological Process

GO:0006695	cholesterol biosynthetic process
GO:0008299	isoprenoid biosynthetic process
GO:0015936	coenzyme A metabolic process
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0051262	protein tetramerization
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005778	peroxisomal membrane
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000731 Sterol-sensing domain
IPR002202 Hydroxymethylglutaryl-CoA reductase, class I/II
IPR003392 Patched
IPR004816 Hydroxymethylglutaryl-CoA reductase, metazoan
IPR009023 Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain
IPR009029 Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain

PFAM

PF00368
PF02460

PRINTS

PR00071

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P04035