InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HPX

Summary

InnateDB Protein

IDBP-28946.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HPX

Protein Name

hemopexin

Synonyms

HX;

Species

Homo sapiens

Ensembl Protein

ENSP00000265983

InnateDB Gene

IDBG-28944 (HPX)

Protein Structure

UniProt Annotation

Function

Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Expressed by the liver and secreted in plasma.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Biological Process

GO:0002639	positive regulation of immunoglobulin production
GO:0002925	positive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0006879	cellular iron ion homeostasis
GO:0015886	heme transport
GO:0016032	viral process
GO:0020027	hemoglobin metabolic process
GO:0042168	heme metabolic process
GO:0042511	positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0051246	regulation of protein metabolic process
GO:0060332	positive regulation of response to interferon-gamma
GO:0060335	positive regulation of interferon-gamma-mediated signaling pathway

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0070062	extracellular vesicular exosome
GO:0071682	endocytic vesicle lumen
GO:0072562	blood microparticle