InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ATP5A1

Summary

InnateDB Protein

IDBP-2904.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP5A1

Protein Name

ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle

Synonyms

ATP5A; ATP5AL2; ATPM; hATP1; HEL-S-123m; MC5DN4; MOM2; OMR; ORM;

Species

Homo sapiens

Ensembl Protein

ENSP00000282050

InnateDB Gene

IDBG-2902 (ATP5A1)

Protein Structure

UniProt Annotation

Function

Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion inner membrane. Cell membrane; Peripheral membrane protein; Extracellular side. Note=Colocalizes with HRG on the cell surface of T-cells.

Disease Associations

Mitochondrial complex V deficiency, nuclear 4 (MC5DN4) [MIM:615228]: A mitochondrial disorder with heterogeneous clinical manifestations including dysmorphic features, psychomotor retardation, hypotonia, growth retardation, cardiomyopathy, enlarged liver, hypoplastic kidneys and elevated lactate levels in urine, plasma and cerebrospinal fluid. {ECO:0000269PubMed:23599390}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Fetal lung, heart, liver, gut and kidney. Expressed at higher levels in the fetal brain, retina and spinal cord. {ECO:0000269PubMed:8428659}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 98 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	98 [view]
Protein-Protein	98 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
GO:0016887	ATPase activity
GO:0022857	transmembrane transporter activity
GO:0042288	MHC class I protein binding
GO:0044822	poly(A) RNA binding
GO:0046933	proton-transporting ATP synthase activity, rotational mechanism
GO:0046961	proton-transporting ATPase activity, rotational mechanism

Biological Process

GO:0001937	negative regulation of endothelial cell proliferation
GO:0006200	ATP catabolic process
GO:0006629	lipid metabolic process
GO:0006754	ATP biosynthetic process
GO:0009790	embryo development
GO:0015986	ATP synthesis coupled proton transport
GO:0015991	ATP hydrolysis coupled proton transport
GO:0015992	proton transport
GO:0022904	respiratory electron transport chain
GO:0042776	mitochondrial ATP synthesis coupled proton transport
GO:0044237	cellular metabolic process
GO:0044281	small molecule metabolic process
GO:0046034	ATP metabolic process

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005753	mitochondrial proton-transporting ATP synthase complex
GO:0005759	mitochondrial matrix
GO:0005886	plasma membrane
GO:0008180	COP9 signalosome
GO:0016020	membrane
GO:0033178	proton-transporting two-sector ATPase complex, catalytic domain
GO:0045261	proton-transporting ATP synthase complex, catalytic core F(1)
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000194 ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain
IPR000793 ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal
IPR004100 ATPase, F1 complex alpha/beta subunit, N-terminal domain
IPR005294 ATPase, F1 complex, alpha subunit
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00006
PF00306
PF02874

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P25705

PhosphoSite