InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HDAC7

Summary

InnateDB Protein

IDBP-29062.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HDAC7

Protein Name

histone deacetylase 7

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000351326

InnateDB Gene

IDBG-29060 (HDAC7)

Protein Structure

UniProt Annotation

Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene. {ECO:0000250, ECO:0000269PubMed:12239305}.

Subcellular Localization

Nucleus. Cytoplasm. Note=In the nucleus, it associates with distinct subnuclear dot-like structures. Shuttles between the nucleus and the cytoplasm. Treatment with EDN1 results in shuttling from the nucleus to the perinuclear region. The export to cytoplasm depends on the interaction with the 14-3-3 protein YWHAE and is due to its phosphorylation.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 149 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	149 [view]
Protein-Protein	85 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	62 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004407	histone deacetylase activity
GO:0005080	protein kinase C binding
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0033613	activating transcription factor binding
GO:0046872	metal ion binding
GO:0046969	NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0046970	NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0070491	repressing transcription factor binding
GO:0071889	14-3-3 protein binding
GO:0097372	NAD-dependent histone deacetylase activity (H3-K18 specific)

Biological Process

GO:0006351	transcription, DNA-templated
GO:0007219	Notch signaling pathway
GO:0016568	chromatin modification
GO:0032703	negative regulation of interleukin-2 production
GO:0045668	negative regulation of osteoblast differentiation
GO:0070932	histone H3 deacetylation
GO:0070933	histone H4 deacetylation
GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis