InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MYH10

Summary

InnateDB Protein

IDBP-29184.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MYH10

Protein Name

myosin, heavy chain 10, non-muscle

Synonyms

NMMHC-IIB; NMMHCB;

Species

Homo sapiens

Ensembl Protein

ENSP00000269243

InnateDB Gene

IDBG-29180 (MYH10)

Protein Structure

UniProt Annotation

Function

Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9. {ECO:0000269PubMed:20052411, ECO:0000269PubMed:20603131}.

Subcellular Localization

Cell projection, lamellipodium {ECO:0000269PubMed:20052411, ECO:0000269PubMed:22480440}. Note=Colocalizes with MCC at the leading edge of migrating cells.

Disease Associations

Tissue Specificity

Isoform 1 is expressed in cerebellum and spinal chord. Isoform 2 is expressed in cerebrum and retina. Isoform 3 is expressed in the cerebrum and to a much lower extent in cerebellum. {ECO:0000269PubMed:7782316}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 67 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	67 [view]
Protein-Protein	67 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000146	microfilament motor activity
GO:0003774	motor activity
GO:0003779	actin binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0030898	actin-dependent ATPase activity
GO:0043531	ADP binding
GO:0051015	actin filament binding

Biological Process

GO:0000281	mitotic cytokinesis
GO:0006200	ATP catabolic process
GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0007411	axon guidance
GO:0008152	metabolic process
GO:0030048	actin filament-based movement
GO:0031032	actomyosin structure organization

Cellular Component

GO:0001725	stress fiber
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005938	cell cortex
GO:0016459	myosin complex
GO:0016460	myosin II complex
GO:0030027	lamellipodium
GO:0030496	midbody
GO:0032154	cleavage furrow
GO:0042641	actomyosin
GO:0097513	myosin II filament

Protein Structure and Domains

PDB ID

InterPro

IPR000048 IQ motif, EF-hand binding site
IPR001609 Myosin head, motor domain
IPR002928 Myosin tail
IPR004009 Myosin, N-terminal, SH3-like
IPR008989 Myosin S1 fragment, N-terminal
IPR009053 Prefoldin
IPR009060 UBA-like
IPR011072 HR1 rho-binding repeat
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00612
PF00063
PF01576
PF02736
PF02185

PRINTS

PR00193

PIRSF

SMART

SM00015
SM00242
SM00742

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt