InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MYH10

Summary

InnateDB Protein

IDBP-29186.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MYH10

Protein Name

myosin, heavy chain 10, non-muscle

Synonyms

NMMHC-IIB; NMMHCB;

Species

Homo sapiens

Ensembl Protein

ENSP00000353590

InnateDB Gene

IDBG-29180 (MYH10)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 67 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	67 [view]
Protein-Protein	67 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000146	microfilament motor activity
GO:0003774	motor activity
GO:0003779	actin binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0030898	actin-dependent ATPase activity
GO:0043531	ADP binding
GO:0051015	actin filament binding

Biological Process

GO:0000281	mitotic cytokinesis
GO:0001701	in utero embryonic development
GO:0001764	neuron migration
GO:0001778	plasma membrane repair
GO:0006200	ATP catabolic process
GO:0006887	exocytosis
GO:0006930	substrate-dependent cell migration, cell extension
GO:0007097	nuclear migration
GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0007409	axonogenesis
GO:0007411	axon guidance
GO:0007420	brain development
GO:0007512	adult heart development
GO:0008152	metabolic process
GO:0008283	cell proliferation
GO:0008360	regulation of cell shape
GO:0021592	fourth ventricle development
GO:0021670	lateral ventricle development
GO:0021678	third ventricle development
GO:0021680	cerebellar Purkinje cell layer development
GO:0030036	actin cytoskeleton organization
GO:0030048	actin filament-based movement
GO:0030239	myofibril assembly
GO:0031032	actomyosin structure organization
GO:0031175	neuron projection development
GO:0050885	neuromuscular process controlling balance
GO:0055003	cardiac myofibril assembly
GO:0055015	ventricular cardiac muscle cell development
GO:0060041	retina development in camera-type eye

Cellular Component

GO:0001725	stress fiber
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005819	spindle
GO:0005886	plasma membrane
GO:0005938	cell cortex
GO:0016459	myosin complex
GO:0016460	myosin II complex
GO:0030027	lamellipodium
GO:0030424	axon
GO:0030426	growth cone
GO:0030496	midbody
GO:0031594	neuromuscular junction
GO:0032154	cleavage furrow
GO:0042641	actomyosin
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0043197	dendritic spine
GO:0097513	myosin II filament

Protein Structure and Domains

PDB ID

InterPro

IPR000048 IQ motif, EF-hand binding site
IPR001609 Myosin head, motor domain
IPR002928 Myosin tail
IPR004009 Myosin, N-terminal, SH3-like
IPR009053 Prefoldin
IPR009060 UBA-like
IPR011072 HR1 rho-binding repeat
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00612
PF00063
PF01576
PF02736
PF02185

PRINTS

PR00193

PIRSF

SMART

SM00015
SM00242
SM00742

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt