InnateDB Protein
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IDBP-2919.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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HAUS1
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Protein Name
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HAUS augmin-like complex, subunit 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000282058
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InnateDB Gene
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IDBG-2917 (HAUS1)
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Protein Structure
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Function |
Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. {ECO:0000269PubMed:15082789, ECO:0000269PubMed:19369198, ECO:0000269PubMed:19427217}.
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Subcellular Localization |
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes with the spindle poles in mitotic cells. In metaphase, localizes to the mitotic asters and is highly punctate on the microtubule array. During later stages of mitosis, remains on the spindle but is not present at the interzone, and is finally observed at the microtubule bundles proximal to the midbody, clearly excluded from the midbody. In contrast, does not colocalize with the tubulin cytoskeleton in interphase cells. In interphase, localized at the centrosome and diffusely in the cytoplasm.
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Disease Associations |
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Tissue Specificity |
Widely expressed. Expressed in pancreas, kidney, skeletal muscle, liver and heart. Weakly expressed in lung, brain and placenta. {ECO:0000269PubMed:15082789}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
34
[view]
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Protein-Protein |
34
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q96CS2
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PhosphoSite |
PhosphoSite-Q96CS2
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
115106
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UniGene |
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RefSeq |
NP_612452
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HUGO |
HGNC:25174
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OMIM |
608775
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CCDS |
CCDS11928
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HPRD |
16385
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IMGT |
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EMBL |
AK097403
AK315605
AY360137
BC005958
BC014003
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GenPept |
AAH05958
AAH14003
AAQ63649
BAC05036
BAG37974
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