InnateDB Protein
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IDBP-2922.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PRMT5
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Protein Name
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protein arginine methyltransferase 5
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Synonyms
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HRMT1L5; IBP72; JBP1; SKB1; SKB1Hs;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000319169
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InnateDB Gene
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IDBG-2920 (PRMT5)
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Protein Structure
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Function |
Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H. Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. Plays a role in the assembly of snRNP core particles. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. May regulate the SUPT5H transcriptional elongation properties. May be part of a pathway that is connected to a chloride current, possibly through cytoskeletal rearrangement. Methylates histone H2A and H4 'Arg-3' during germ cell development. Methylates histone H3 'Arg-8', which may repress transcription. Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage. Methylates RPS10. Attenuates EGF signaling through the MAPK1/MAPK3 pathway acting at 2 levels. First, monomethylates EGFR; this enhances EGFR 'Tyr-1197' phosphorylation and PTPN6 recruitment, eventually leading to reduced SOS1 phosphorylation. Second, methylates RAF1 and probably BRAF, hence destabilizing these 2 signaling proteins and reducing their catalytic activity. Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation. Methylates HOXA9. Methylates and regulates SRGAP2 which is involved in cell migration and differentiation. Acts as a transcriptional corepressor in CRY1-mediated repression of the core circadian component PER1 by regulating the H4R3 dimethylation at the PER1 promoter. {ECO:0000269PubMed:10531356, ECO:0000269PubMed:11152681, ECO:0000269PubMed:11747828, ECO:0000269PubMed:12411503, ECO:0000269PubMed:15737618, ECO:0000269PubMed:17709427, ECO:0000269PubMed:20159986, ECO:0000269PubMed:20810653, ECO:0000269PubMed:21258366, ECO:0000269PubMed:21917714, ECO:0000269PubMed:22269951}.
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Subcellular Localization |
Cytoplasm. Nucleus.
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Disease Associations |
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Tissue Specificity |
Ubiquitous.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 217 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Experimentally validated |
Total |
217
[view]
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Protein-Protein |
211
[view]
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Protein-DNA |
6
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
21 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR007857
Protein arginine N-methyltransferase PRMT5
IPR025799
Protein arginine N-methyltransferase
IPR029063
S-adenosyl-L-methionine-dependent methyltransferase-like
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PFAM |
PF05185
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PRINTS |
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PIRSF |
PIRSF015894
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O14744
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PhosphoSite |
PhosphoSite-O14744
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TrEMBL |
G3V5T6
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UniProt Splice Variant |
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Entrez Gene |
10419
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UniGene |
Hs.367854
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RefSeq |
NP_006100
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HUGO |
HGNC:10894
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OMIM |
604045
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CCDS |
CCDS9579
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HPRD |
04955
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IMGT |
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EMBL |
AB451246
AB451370
AF015913
AF167572
AK075251
AK300863
AK301812
AK302240
AL132780
BC005820
BC025979
CH471078
CR456741
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GenPept |
AAB66581
AAF04502
AAH25979
BAG52095
BAG62512
BAG63261
BAG63592
BAG70060
BAG70184
CAG33022
EAW66218
EAW66219
EAW66220
EAW66221
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