Version 5.4
Homo sapiens Protein: SHCBP1
Summary
InnateDB Protein IDBP-29228.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SHCBP1
Protein Name SHC SH2-domain binding protein 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000306473
InnateDB Gene IDBG-29226 (SHCBP1)
Protein Structure
UniProt Annotation
Function May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042169 SH2 domain binding
Biological Process
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:2000177 regulation of neural precursor cell proliferation
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR006626 Parallel beta-helix repeat
IPR011050 Pectin lyase fold/virulence factor
PFAM
PRINTS
PIRSF
SMART SM00710
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NEM2
PhosphoSite PhosphoSite-Q8NEM2
TrEMBL
UniProt Splice Variant
Entrez Gene 79801
UniGene Hs.123253
RefSeq NP_079021
HUGO HGNC:29547
OMIM 611027
CCDS CCDS10720
HPRD 11557
IMGT
EMBL AC092368 AK025662 AK055931 BC000960 BC030699
GenPept AAH00960 AAH30699 BAB15208 BAB71049

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca