Version 5.4
Homo sapiens Protein: INPP5K
Summary
InnateDB Protein IDBP-292480.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol INPP5K
Protein Name inositol polyphosphate-5-phosphatase K
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000385177
InnateDB Gene IDBG-14904 (INPP5K)
Protein Structure
UniProt Annotation
Function Inositol 5-phosphatase which acts on inositol 1,4,5- trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5- trisphosphate. May negatively regulate assembly of the actin cytoskeleton. {ECO:0000269PubMed:10753883}.
Subcellular Localization Endoplasmic reticulum {ECO:0000269PubMed:12536145}. Note=Following stimulation with EGF, translocates to membrane ruffles.
Disease Associations
Tissue Specificity Ubiquitously expressed with highest levels in skeletal muscle, heart and kidney. {ECO:0000269PubMed:10753883}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
Experimentally validated
Total 26 [view]
Protein-Protein 26 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004445 inositol-polyphosphate 5-phosphatase activity
GO:0005000 vasopressin receptor activity
GO:0005515 protein binding
GO:0016312 inositol bisphosphate phosphatase activity
GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
GO:0034594 phosphatidylinositol trisphosphate phosphatase activity
GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity
GO:0042577 lipid phosphatase activity
GO:0046030 inositol trisphosphate phosphatase activity
GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity
GO:0052659 inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
Biological Process
GO:0001933 negative regulation of protein phosphorylation
GO:0005979 regulation of glycogen biosynthetic process
GO:0006469 negative regulation of protein kinase activity
GO:0006644 phospholipid metabolic process
GO:0006661 phosphatidylinositol biosynthetic process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0010801 negative regulation of peptidyl-threonine phosphorylation
GO:0010829 negative regulation of glucose transport
GO:0016311 dephosphorylation
GO:0030036 actin cytoskeleton organization
GO:0032869 cellular response to insulin stimulus
GO:0032870 cellular response to hormone stimulus
GO:0033137 negative regulation of peptidyl-serine phosphorylation
GO:0035305 negative regulation of dephosphorylation
GO:0035810 positive regulation of urine volume
GO:0042593 glucose homeostasis
GO:0043407 negative regulation of MAP kinase activity
GO:0043922 negative regulation by host of viral transcription
GO:0044281 small molecule metabolic process
GO:0045719 negative regulation of glycogen biosynthetic process
GO:0045869 negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0046855 inositol phosphate dephosphorylation
GO:0046856 phosphatidylinositol dephosphorylation
GO:0051497 negative regulation of stress fiber assembly
GO:0051898 negative regulation of protein kinase B signaling
GO:0051926 negative regulation of calcium ion transport
GO:0071320 cellular response to cAMP
GO:0071356 cellular response to tumor necrosis factor
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0072661 protein targeting to plasma membrane
GO:0090315 negative regulation of protein targeting to membrane
GO:0097178 ruffle assembly
GO:2000466 negative regulation of glycogen (starch) synthase activity
GO:2001153 positive regulation of renal water transport
Cellular Component
GO:0001726 ruffle
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005802 trans-Golgi network
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0032587 ruffle membrane
GO:0043005 neuron projection
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000300 Inositol polyphosphate-related phosphatase
IPR005135 Endonuclease/exonuclease/phosphatase
PFAM PF03372
PF14529
PRINTS
PIRSF
SMART SM00128
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BT40
PhosphoSite PhosphoSite-Q9BT40
TrEMBL K7EPG6
UniProt Splice Variant
Entrez Gene 51763
UniGene Hs.632238
RefSeq NP_001129114
HUGO HGNC:33882
OMIM 607875
CCDS CCDS11005
HPRD 08489
IMGT
EMBL AB036829 AB036830 AB036831 AC100748 AK297955 AK312585 AK312844 BC004362 CH471108 U45973
GenPept AAB03214 AAH04362 BAA92340 BAA92341 BAA92342 BAG35479 BAG35697 BAH12695 EAW90614 EAW90615 EAW90618

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca