Version 5.4
Homo sapiens Protein: SERPIND1
Summary
InnateDB Protein IDBP-292617.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SERPIND1
Protein Name serpin peptidase inhibitor, clade D (heparin cofactor), member 1
Synonyms D22S673; HC2; HCF2; HCII; HLS2; LS2; THPH10;
Species Homo sapiens
Ensembl Protein ENSP00000384050
InnateDB Gene IDBG-1808 (SERPIND1)
Protein Structure
UniProt Annotation
Function Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner. {ECO:0000269PubMed:1939083}.Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils. {ECO:0000269PubMed:1939083}.
Subcellular Localization
Disease Associations Thrombophilia due to heparin cofactor 2 deficiency (THPH10) [MIM:612356]: A hemostatic disorder characterized by a tendency to recurrent thrombosis. {ECO:0000269PubMed:10391209, ECO:0000269PubMed:11204559, ECO:0000269PubMed:15337701, ECO:0000269PubMed:2647747}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity Expressed predominantly in liver. Also present in plasma.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004866 endopeptidase inhibitor activity
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0008201 heparin binding
Biological Process
GO:0006935 chemotaxis
GO:0007596 blood coagulation
GO:0010951 negative regulation of endopeptidase activity
GO:0030162 regulation of proteolysis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR023796 Serpin domain
PFAM PF00079
PRINTS
PIRSF
SMART SM00093
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P05546
PhosphoSite PhosphoSite-P05546
TrEMBL
UniProt Splice Variant
Entrez Gene 3053
UniGene Hs.474270
RefSeq
HUGO HGNC:4838
OMIM 142360
CCDS CCDS13783
HPRD 00795
IMGT
EMBL AK314200 CH471176 CR456573 M12849 M33660 M58600 X03498
GenPept AAA36185 AAA52641 AAA52642 BAG36878 CAA27218 CAG30459 EAX02941 EAX02942

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca