InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AKR1C2

Summary

InnateDB Protein

IDBP-292651.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AKR1C2

Protein Name

aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)

Synonyms

AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD; HBAB; MCDR2; SRXY8; TDD;

Species

Homo sapiens

Ensembl Protein

ENSP00000385221

InnateDB Gene

IDBG-47297 (AKR1C2)

Protein Structure

UniProt Annotation

Function

Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones into the 3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5-alpha- DHT) to 5-alpha-androstane-3-alpha,17-beta-diol (3-alpha-diol). Has a high bile-binding ability. {ECO:0000269PubMed:15929998, ECO:0000269PubMed:17034817, ECO:0000269PubMed:17442338, ECO:0000269PubMed:8573067}.

Subcellular Localization

Cytoplasm {ECO:0000305}.

Disease Associations

46,XY sex reversal 8 (SRXY8) [MIM:614279]: A disorder of sex development. Affected individuals have a 46,XY karyotype but present as phenotypically normal females. {ECO:0000269PubMed:21802064}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed in fetal testes. Expressed in fetal and adult adrenal glands. {ECO:0000269PubMed:21802064}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	3 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004032	alditol:NADP+ 1-oxidoreductase activity
GO:0004958	prostaglandin F receptor activity
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
GO:0018636	phenanthrene 9,10-monooxygenase activity
GO:0031406	carboxylic acid binding
GO:0032052	bile acid binding
GO:0047086	ketosteroid monooxygenase activity
GO:0047115	trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity

Biological Process

GO:0006693	prostaglandin metabolic process
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007586	digestion
GO:0008202	steroid metabolic process
GO:0008284	positive regulation of cell proliferation
GO:0030855	epithelial cell differentiation
GO:0034694	response to prostaglandin stimulus
GO:0042448	progesterone metabolic process
GO:0044597	daunorubicin metabolic process
GO:0044598	doxorubicin metabolic process
GO:0051897	positive regulation of protein kinase B signaling
GO:0055114	oxidation-reduction process
GO:0071395	cellular response to jasmonic acid stimulus