Version 5.4
Homo sapiens Protein: COLEC11
Summary
InnateDB Protein IDBP-292692.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol COLEC11
Protein Name collectin sub-family member 11
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000384882
InnateDB Gene IDBG-26615 (COLEC11)
Protein Structure
UniProt Annotation
Function Lectin that binds to various sugars including fucose and mannose. Has a higher affinity for fucose compared to mannose. Does not bind to glucose, N-acetylglucosamine and N- acetylgalactosamine. Also binds lipopolysaccharides (LPS). Involved in fundamental development serving as a guidance cue for neural crest cell migration (By similarity). {ECO:0000250}.
Subcellular Localization Secreted {ECO:0000305}.
Disease Associations 3MC syndrome 2 (3MC2) [MIM:265050]: A disorder characterized by facial dysmorphism that includes hypertelorism, blepharophimosis, blepharoptosis and highly arched eyebrows, cleft lip and/or palate, craniosynostosis, learning disability and genital, limb and vesicorenal anomalies. The term 3MC syndrome includes Carnevale, Mingarelli, Malpuech, and Michels syndromes. {ECO:0000269PubMed:21258343}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity Ubiquitous. {ECO:0000269PubMed:17179669}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005537 mannose binding
Biological Process
GO:0007275 multicellular organismal development
GO:0032502 developmental process
Cellular Component
GO:0005576 extracellular region
GO:0005581 collagen trimer
Protein Structure and Domains
PDB ID
InterPro IPR001304 C-type lectin
IPR008160 Collagen triple helix repeat
IPR016187 C-type lectin fold
PFAM PF00059
PF01391
PRINTS
PIRSF
SMART SM00034
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BWP8
PhosphoSite PhosphoSite-Q9BWP8
TrEMBL
UniProt Splice Variant
Entrez Gene 78989
UniGene Hs.32603
RefSeq NP_001242916
HUGO HGNC:17213
OMIM 612502
CCDS CCDS58693
HPRD 10847
IMGT
EMBL AB119525 AB119650 AB119651 AB119652 AB119684 AB119685 AB119686 AB119687 AC010907 AK303824 AK313840 AY358439 BC000078 BC009951 CH471053 CR936641
GenPept AAH00078 AAH09951 AAQ88805 AAY24235 BAF43301 BAF43302 BAF43303 BAF43304 BAF79604 BAF79605 BAF79606 BAF79607 BAG36572 BAG64772 CAI56781 EAX01053 EAX01054 EAX01055

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca