InnateDB Protein
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IDBP-292821.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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GPR35
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Protein Name
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G protein-coupled receptor 35
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000385140
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InnateDB Gene
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IDBG-84854 (GPR35)
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Protein Structure
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Function |
Acts as a receptor for kynurenic acid, an intermediate in the tryptophan metabolic pathway. The activity of this receptor is mediated by G-proteins that elicit calcium mobilization and inositol phosphate production through G(qi/o) proteins. {ECO:0000269PubMed:16754668}.
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Subcellular Localization |
Cell membrane {ECO:0000269PubMed:16754668}; Multi-pass membrane protein {ECO:0000269PubMed:16754668}. Note=Internalized to the cytoplasm after exposure to kynurenic acid.
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Disease Associations |
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Tissue Specificity |
Predominantly expressed in immune and gastrointestinal tissues. {ECO:0000269PubMed:16754668}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0004930
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G-protein coupled receptor activity
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Biological Process |
GO:0007186
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G-protein coupled receptor signaling pathway
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Cellular Component |
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PDB ID |
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InterPro |
IPR000276
G protein-coupled receptor, rhodopsin-like
IPR017452
GPCR, rhodopsin-like, 7TM
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PFAM |
PF00001
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PRINTS |
PR00237
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9HC97
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PhosphoSite |
PhosphoSite-Q9HC97
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
2859
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UniGene |
Hs.112218
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RefSeq |
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HUGO |
HGNC:4492
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OMIM |
602646
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CCDS |
CCDS2541
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HPRD |
16003
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IMGT |
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EMBL |
AC124862
AF027957
AF089087
AK172786
AY275467
BC095500
BC117453
BC117455
CR541765
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GenPept |
AAC52028
AAG17965
AAH95500
AAI17454
AAI17456
AAP32299
AAX88945
CAG46564
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