Version 5.4
Homo sapiens Protein: GPR35
Summary
InnateDB Protein IDBP-292822.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GPR35
Protein Name G protein-coupled receptor 35
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000384263
InnateDB Gene IDBG-84854 (GPR35)
Protein Structure
UniProt Annotation
Function Acts as a receptor for kynurenic acid, an intermediate in the tryptophan metabolic pathway. The activity of this receptor is mediated by G-proteins that elicit calcium mobilization and inositol phosphate production through G(qi/o) proteins. {ECO:0000269PubMed:16754668}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:16754668}; Multi-pass membrane protein {ECO:0000269PubMed:16754668}. Note=Internalized to the cytoplasm after exposure to kynurenic acid.
Disease Associations
Tissue Specificity Predominantly expressed in immune and gastrointestinal tissues. {ECO:0000269PubMed:16754668}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM
PFAM PF00001
PRINTS PR00237
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9HC97
PhosphoSite PhosphoSite-Q9HC97
TrEMBL
UniProt Splice Variant
Entrez Gene 2859
UniGene Hs.112218
RefSeq NP_005292
HUGO HGNC:4492
OMIM 602646
CCDS CCDS2541
HPRD 16003
IMGT
EMBL AC124862 AF027957 AF089087 AK172786 AY275467 BC095500 BC117453 BC117455 CR541765
GenPept AAC52028 AAG17965 AAH95500 AAI17454 AAI17456 AAP32299 AAX88945 CAG46564

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca