Version 5.4
Homo sapiens Protein: EIF4E2
Summary
InnateDB Protein IDBP-292904.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF4E2
Protein Name eukaryotic translation initiation factor 4E family member 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000386996
InnateDB Gene IDBG-83304 (EIF4E2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 39 [view]
Protein-Protein 39 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000339 RNA cap binding
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity
GO:0005515 protein binding
GO:0008135 translation factor activity, nucleic acid binding
GO:0031625 ubiquitin protein ligase binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006413 translational initiation
GO:0017148 negative regulation of translation
GO:0019221 cytokine-mediated signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005845 mRNA cap binding complex
Protein Structure and Domains
PDB ID
InterPro IPR001040 Translation Initiation factor eIF- 4e
IPR023398 Translation Initiation factor eIF- 4e-like domain
PFAM PF01652
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O60573
PhosphoSite PhosphoSite-O60573
TrEMBL Q59FE1
UniProt Splice Variant
Entrez Gene 9470
UniGene Hs.598884
RefSeq NP_001263265
HUGO HGNC:3293
OMIM 605895
CCDS CCDS63159
HPRD 05798
IMGT
EMBL AB209519 AC073254 AC092165 AC093383 AF038957 AF047695 AF068117 BC005392 BC005874 BC021226 BC021690 CH471063
GenPept AAC18565 AAC19374 AAC39871 AAH05392 AAH05874 AAH21226 AAH21690 BAD92756 EAW71008

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca