InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TNFSF18

Summary

InnateDB Protein

IDBP-292987.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNFSF18

Protein Name

tumor necrosis factor (ligand) superfamily, member 18

Synonyms

AITRL; GITRL; hGITRL; TL6;

Species

Homo sapiens

Ensembl Protein

ENSP00000385470

InnateDB Gene

IDBG-104861 (TNFSF18)

Protein Structure

UniProt Annotation

Function

Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T- cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. {ECO:0000269PubMed:17449724, ECO:0000269PubMed:18040044}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:17449724}; Single-pass type II membrane protein {ECO:0000269PubMed:17449724}.

Disease Associations

Tissue Specificity

Expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005125	cytokine activity
GO:0005164	tumor necrosis factor receptor binding
GO:0005515	protein binding
GO:0032813	tumor necrosis factor receptor superfamily binding

Biological Process

GO:0002309	T cell proliferation involved in immune response
GO:0006955	immune response
GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0033209	tumor necrosis factor-mediated signaling pathway
GO:0042129	regulation of T cell proliferation
GO:0043066	negative regulation of apoptotic process
GO:0051092	positive regulation of NF-kappaB transcription factor activity