InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: XRCC6

Summary

InnateDB Protein

IDBP-293253.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

XRCC6

Protein Name

X-ray repair complementing defective repair in Chinese hamster cells 6

Synonyms

CTC75; CTCBF; G22P1; KU70; ML8; TLAA;

Species

Homo sapiens

Ensembl Protein

ENSP00000384082

InnateDB Gene

IDBG-9323 (XRCC6)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 347 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	347 [view]
Protein-Protein	341 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003684	damaged DNA binding
GO:0004003	ATP-dependent DNA helicase activity
GO:0042162	telomeric DNA binding

Biological Process

GO:0000723	telomere maintenance
GO:0006303	double-strand break repair via nonhomologous end joining
GO:0032508	DNA duplex unwinding

Cellular Component

GO:0005634	nucleus
GO:0043564	Ku70:Ku80 complex

Protein Structure and Domains

PDB ID

InterPro

IPR002035 von Willebrand factor, type A
IPR003034 SAP domain
IPR005160 Ku70/Ku80 C-terminal arm
IPR005161 Ku70/Ku80, N-terminal alpha/beta
IPR006164 Ku70/Ku80 beta-barrel domain
IPR006165 Ku70
IPR016194 SPOC like C-terminal domain

PFAM

PF00092
PF02037
PF03730
PF03731
PF02735

PRINTS

PIRSF

PIRSF003033

SMART

SM00327
SM00513
SM00559

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt