InnateDB Protein
|
IDBP-293257.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
HECW2
|
Protein Name
|
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000386775
|
InnateDB Gene
|
IDBG-77770 (HECW2)
|
Protein Structure
|
|
Function |
E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73. {ECO:0000269PubMed:12890487}.
|
Subcellular Localization |
Cytoplasm {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
Predominantly expressed in adult brain, lung and heart. {ECO:0000269PubMed:12890487}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 286 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
286
[view]
|
Protein-Protein |
286
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
GO:0042787
|
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
|
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR000569
HECT
IPR001202
WW domain
|
PFAM |
PF00632
PF00397
|
PRINTS |
|
PIRSF |
|
SMART |
SM00119
SM00456
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q9P2P5
|
PhosphoSite |
PhosphoSite-Q9P2P5
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
57520
|
UniGene |
Hs.654742
|
RefSeq |
|
HUGO |
HGNC:29853
|
OMIM |
|
CCDS |
|
HPRD |
17099
|
IMGT |
|
EMBL |
AB037722
AC020571
AC068544
AC073905
AC074090
AC093379
AL390186
BC117194
BC117198
CR749424
|
GenPept |
AAI17195
AAI17199
BAA92539
CAB99103
CAH18262
|
|
|