InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MTIF2

Summary

InnateDB Protein

IDBP-293292.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MTIF2

Protein Name

mitochondrial translational initiation factor 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000384481

InnateDB Gene

IDBG-52399 (MTIF2)

Protein Structure

UniProt Annotation

Function

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

Subcellular Localization

Mitochondrion.

Disease Associations

Tissue Specificity

Expressed in all tissues examined. Highest level in skeletal muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003743	translation initiation factor activity
GO:0003924	GTPase activity
GO:0005525	GTP binding
GO:0008135	translation factor activity, nucleic acid binding
GO:0043024	ribosomal small subunit binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0001732	formation of translation initiation complex
GO:0006184	GTP catabolic process
GO:0006446	regulation of translational initiation
GO:0007264	small GTPase mediated signal transduction
GO:0032790	ribosome disassembly

Cellular Component

GO:0005622	intracellular
GO:0005739	mitochondrion

Protein Structure and Domains

PDB ID

InterPro

IPR000795 Elongation factor, GTP-binding domain
IPR001806 Small GTPase superfamily
IPR004161 Translation elongation factor EFTu/EF1A, domain 2
IPR005225 Small GTP-binding protein domain
IPR006073 GTP binding domain
IPR009000 Translation protein, beta-barrel domain
IPR013684 Mitochondrial Rho-like
IPR019009 Signal recognition particle receptor, beta subunit
IPR023115 Translation initiation factor IF- 2, domain 3
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM