Version 5.4
Homo sapiens Protein: PARG
Summary
InnateDB Protein IDBP-293351.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PARG
Protein Name poly (ADP-ribose) glycohydrolase
Synonyms PARG99;
Species Homo sapiens
Ensembl Protein ENSP00000384408
InnateDB Gene IDBG-304161 (PARG)
Protein Structure
UniProt Annotation
Function Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. PARG acts both as an endo- and exoglycosidase, releasing PAR of different length as well as ADP-ribose monomers. Required for retinoid acid-dependent gene transactivation, probably by dePARsylating histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters. {ECO:0000269PubMed:23102699}.
Subcellular Localization Isoform 1: Nucleus {ECO:0000269PubMed:16460818, ECO:0000269PubMed:21398629}. Note=Colocalizes with PCNA at replication foci. Relocalizes to the cytoplasm in response to DNA damage.Isoform 2: Cytoplasm {ECO:0000269PubMed:16460818}. Note=Translocates to the nucleus in response to DNA damage.Isoform 3: Cytoplasm.Isoform 4: Cytoplasm. Mitochondrion.Isoform 5: Mitochondrion matrix.
Disease Associations
Tissue Specificity Ubiquitously expressed. {ECO:0000269PubMed:14527731}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 4 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004649 poly(ADP-ribose) glycohydrolase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006974 cellular response to DNA damage stimulus
GO:0016045 detection of bacterium
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR007724 Poly(ADP-ribose) glycohydrolase
PFAM PF05028
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q86W56
PhosphoSite PhosphoSite-Q86W56
TrEMBL B4DX76
UniProt Splice Variant
Entrez Gene 8505
UniGene Hs.732225
RefSeq
HUGO HGNC:8605
OMIM 603501
CCDS CCDS73130
HPRD 04611
IMGT
EMBL AF005043 AK295244 AK295786 AK301845 AK302560 AK314909 AY258587 AY575848 AY575849 BC050560 BC052966 EF382674 JQ890226
GenPept AAB61614 AAH50560 AAH52966 AAP83314 AAT66421 AAT66422 ABR10027 AFM56043 BAG37421 BAG58236 BAG58607 BAG63288 BAG63826

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca