InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MSH2

Summary

InnateDB Protein

IDBP-293510.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MSH2

Protein Name

mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)

Synonyms

COCA1; FCC1; HNPCC; HNPCC1; LCFS2;

Species

Homo sapiens

Ensembl Protein

ENSP00000384199

InnateDB Gene

IDBG-50900 (MSH2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 130 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	132 [view]
Protein-Protein	132 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005524	ATP binding
GO:0030983	mismatched DNA binding

Biological Process

GO:0006298

mismatch repair

Cellular Component

GO:0032301	MutSalpha complex
GO:0032302	MutSbeta complex

Protein Structure and Domains

PDB ID

InterPro

IPR000432 DNA mismatch repair protein MutS, C-terminal
IPR007695 DNA mismatch repair protein MutS-like, N-terminal
IPR007696 DNA mismatch repair protein MutS, core
IPR007860 DNA mismatch repair protein MutS, connector domain
IPR007861 DNA mismatch repair protein MutS, clamp
IPR011184 DNA mismatch repair protein, MSH2
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00488
PF01624
PF05192
PF05188
PF05190

PRINTS

PIRSF

PIRSF005813

SMART

SM00534
SM00533

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt