InnateDB Protein
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IDBP-293512.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SUN2
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Protein Name
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Sad1 and UNC84 domain containing 2
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Synonyms
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UNC84B;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000385740
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InnateDB Gene
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IDBG-7758 (SUN2)
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Protein Structure
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Function |
Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5. {ECO:0000269PubMed:18396275}.
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Subcellular Localization |
Nucleus inner membrane; Single-pass type II membrane protein. Endosome membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Widely expressed. Highly expressed in heart, lung and muscle. Weakly expressed in fetal heart. Slightly overexpressed in some heart tissues form patients with congenital heart defects. {ECO:0000269PubMed:10818110, ECO:0000269PubMed:12393179}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
24
[view]
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Protein-Protein |
24
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR008979
Galactose-binding domain-like
IPR012919
Sad1/UNC-like, C-terminal
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PFAM |
PF07738
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UH99
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PhosphoSite |
PhosphoSite-Q9UH99
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TrEMBL |
Q6NT72
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UniProt Splice Variant |
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Entrez Gene |
25777
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UniGene |
Hs.740137
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RefSeq |
NP_056189
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HUGO |
HGNC:14210
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OMIM |
613569
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CCDS |
CCDS13978
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HPRD |
15611
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IMGT |
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EMBL |
AB014568
AF202723
AL008583
AL021707
AL021806
AY682988
BC030684
BC069253
BC094797
BC111549
BC111717
BX537962
CH471095
CR456474
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GenPept |
AAF15887
AAH30684
AAH69253
AAH94797
AAI11550
AAI11718
AAT90500
BAA31643
CAD97926
CAG30360
CAI21604
CAQ07913
EAW60266
EAW60268
EAW60270
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