InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SUN2

Summary

InnateDB Protein

IDBP-293515.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SUN2

Protein Name

Sad1 and UNC84 domain containing 2

Synonyms

UNC84B;

Species

Homo sapiens

Ensembl Protein

ENSP00000383992

InnateDB Gene

IDBG-7758 (SUN2)

Protein Structure

UniProt Annotation

Function

Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5. {ECO:0000269PubMed:18396275}.

Subcellular Localization

Nucleus inner membrane; Single-pass type II membrane protein. Endosome membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Widely expressed. Highly expressed in heart, lung and muscle. Weakly expressed in fetal heart. Slightly overexpressed in some heart tissues form patients with congenital heart defects. {ECO:0000269PubMed:10818110, ECO:0000269PubMed:12393179}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005521	lamin binding
GO:0008017	microtubule binding
GO:0042802	identical protein binding

Biological Process

GO:0006998	nuclear envelope organization
GO:0007052	mitotic spindle organization
GO:0007097	nuclear migration
GO:0030335	positive regulation of cell migration
GO:0031022	nuclear migration along microfilament
GO:0051642	centrosome localization
GO:0090286	cytoskeletal anchoring at nuclear membrane
GO:0090292	nuclear matrix anchoring at nuclear membrane

Cellular Component

GO:0005635	nuclear envelope
GO:0005637	nuclear inner membrane
GO:0010008	endosome membrane
GO:0016021	integral component of membrane
GO:0031965	nuclear membrane
GO:0034993	SUN-KASH complex